Showing 251 results for the keyword: Lung
- The current standard of care for advanced lung cancer and cancers of the thymus consists
primarily of chemotherapy treatment. The drugs used for chemotherapy depend on the
classification of the cancer in different categories that are based on the appearance of the
cancer in the micro...
Background: CRLX101 consists of a sugar molecule cyclodextrin linked to a chemotherapy drug
called camptothecin. The combined molecule or nanoparticle drug conjugate travels through
the blood. Once inside cancer cells, the chemotherapy drug is released from the molecule.
Olaparib is a drug that may stop ...
-This protocol will provide a means for screening potential candidates for NCI Radiation
Oncology Branch (ROB) protocols.
-To permit evaluation of patients referred to the NCI Radiation Oncology Branch in order to
identify individuals who will be suitable candidates...
Some non-small-cell lung cancers (NSCLC) have a mutation in a gene that makes a protein
called EGFR. This particular cancer can be treated with certain drugs such as Erlotinib
(Tarceva), Gefitinib (Iressa) and Osimertinib (Tagrisso). But many tumors become resistant
to these drugs beca...
This study will examine 1) the role of hereditary factors in cystic fibrosis; i.e., the
relationship of the disease to specific gene variations, and 2) the role of bacterial
products involved in lung infections substances produced by bacteria may worsen the disease.
Patients with cystic fibrosis who are...
Anetumab ravtansine is a new drug. It kills cancer cells that carry mesothelin. That is a
protein on the surface of tumor cells in many types of tumors, including most lung cancers.
Researchers want to find a safe dose for the study drug for lung cancer. They want to see if
it can shri...
Mithramycin is a new cancer drug. In another study, people with chest cancer took the drug 6
hours a day for 7 straight days. Many of them had liver damage as a side effect. It was
discovered that only people with certain genes got this side effect. Researchers want to
Chemotherapy damages cancer cell DNA so the cells die and the tumor shrinks. But it may stop
working in some people over time. This is partly due to efficient DNA damage repair
mechanisms used by tumor cells. VX-970 may stop cancer cells from preventing the repair of
DNA damaged by che...
The Laboratory of Human Carcinogenesis and the Pharmocogenetics Section of the Genetic
Epidemiology Branch will conduct a lung cancer case-control study in Baltimore, Maryland.
The primary hypothesis of the study is to determine if mutagen sensitivity, p53 induction
and apoptosis in cultured lymphocytes ...
Phase I study to establish safety and feasibility of intravenous or intrapleural
administered lentiviral transduced huCART-meso cells with or without lymphodepletion.
Intravenous administration of huCART-meso cells is planned with or without cyclophosphamide
as lymphodepleting chemotherapy.